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Figure 2C presents the RSCU for the 10% most highly biased genes in each species as indicated by ENC.
Genome-wide patterns of codon bias are driven primarily by the most highly biased genes, which, if they share preferred codons, will dominate the synonymous codon usage patterns.
Furthermore, we observe that the association between major codons and evolutionary conserved sites is strongest in the most highly biased genes.
The magnitude of codon bias exhibited strong correlations with mean GC3 and GC cds in the most highly biased groups (0 and 1).
A preference for G or C in N3 is seen in the most highly biased genes of Drosophila, which is almost entirely explained by an increased use of C over G (Shields et al. 1988).
In addition, assuming that orthologous genes in D. melanogaster and D. saltans/willistoni are under similar selection pressures for codon bias, the changing codon preference model predicts that genes with the most highly biased patterns of codon usage will experience the greatest deviation in codon usage patterns relative to D. melanogaster, which is precisely what is observed [ 27].
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4– 6 Consequently, these series most frequently present highly biased findings retrieved from super-selected cohorts: it is only the superfit onco-geriatric patient that reaches surgical theater.
However, the usually small number of samples per class in most studies and the highly biased cross validation procedures cast doubt on the classification accuracy in terms of their statistical significance [ 5].
The site has compiled the data to create Alexa-like graphs, though most of the data is highly biased towards the tech-savvy.
Since television and most other media are owned or run by the state, respondents get most of their information from a highly biased source.
Numerous reports have also been published on the differential expression of kinase genes and proteins in specific types of cancers, but these results are highly biased towards the most commonly studied kinase genes and towards common cancer forms.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com