Sentence examples for most highly activated from inspiring English sources

However, MuRF2−/− hearts also have the most highly activated PPARγ1 activity by several measures (Figs.  1a, 4d), indicating that the strong post-translational multi-mono-ubiquitination in vitro (Fig.  6g) may be MuRF2's primary mechanism of regulating PPARγ1 in vivo.

In contrast to the colon, where TNFα cascade, tight junction and immune response signaling were most highly activated; jejunum was the segment with the strongest activation of apoptosis, cell cycle control/DNA damage repair and coagulation system signaling after irradiation.

CXCL10 was chosen because it was the most highly activated inflammatory gene based on the microarray datasets.

However, the −92 bp fragment was the most highly activated construct by TIEG1 at the transcriptional level (Figure 5C) suggesting that repression domains are located between −288 and −92 bps which inhibit optimal activation of the Runx2 promoter by TIEG1.

Phased remodeling sites are not the most highly "activated" enhancers (Fig.  5b, c), having lower H3K27Ac and DHS than sites of non-central remodeling.

Within the NF-κB induced pathway, cytokine and chemokine genes were amongst the most highly activated genes at both time points, and in both subject groups.

Interestingly, the five most highly transcriptionally activated genes in a CRC cell line following 5-FU exposure all possess putative p53 response elements (Maxwell et al, 2003).

Most likely the TGFβ receptor is highly activated on the basal membrane in this model, non-specific staining could account for this, but similar isotype antibodies did not give the same staining pattern in 3D culture, (see CXCR4, FGFR2 and Pearson et al., [22]).

On the other hand, the enzyme was highly activated by its activators NH4+, AMP and F2,6P [33].

In this instance, of the 7 highly activated TFs, codY was the most significant predictor discriminating WCH16 from WCH43 in the blood, where its coefficient was -38 in WCH16, compared to +13 in WCH43.

Protein metabolism also was highly activated, with protein transport being the most enriched process, particularly protein targeting which was increased.