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While most guidelines for assessing the validity of observational studies apply to administrative database research, the unique data source and analytical opportunities for these studies create risks that can make them uninterpretable or bias their results.
Overall, these data led to recommendations in most guidelines for more than one drug as first-line treatment for the long-term treatment of bipolar disorder.
Most guidelines for the treatment of psychiatric disorders are evidence-based guidelines (EBG) [ 11, 20].
Most guidelines for prophylactic mastectomy address women at high risk, not women with unilateral cancer.
Exercise interventions are recommended in most guidelines for the treatment of type 2 diabetes.
Until recently, aspirin was recommended by most guidelines for the primary prevention of cardiovascular events in people with diabetes.
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Yet high costs and expensive technologies needed to enforce international protocols render most guidelines unenforceable for most African countries.
Until recently, most guidelines recommended treatment for primary prevention for those with a 20% or greater 10-year risk of developing CVD.
Some variability exists among national guidelines for mammography frequency, but most guidelines recommend annual mammography for women over 50 [ 18].
In addition, most guidelines recommend referral for psychological interventions in certain cases, although criteria differ between guidelines [ 3- 7].
Previously, most guidelines were developed for RCTs [ 10], but now we found increasing attention was on other types of health research.
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