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Most genes indicated in these studies have been linked to urate transport; this is because most individuals tend to maintain renal urate excretion ability to some extent, which compensates for serum urate concentrations even under conditions of urate overproduction.
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Our observations revealed that mitotic activity decreased significantly at this time point after inhibition of most genes, indicating that many neoblast regulators could control neoblast proliferation generally (Fig. 1B).
Averaging over the whole gene, a dN/ dS < 1 was obtained for most genes, indicating fairly strong purifying selection.
The locations of the probesets are shown as red asterisks with the 50 most significant genes indicated.
Px-0019 was a Papilio-specific highly expressed gene based on a comparison of the 30 most highly expressed genes (indicated by green circles in Figure 1).
Although the analysis of the modulated expression of genes did not indicate a significant increase in the expression of transporters (Fig. 3), a survey of the most highly expressed genes indicated that many cellular transport systems are induced in germinating conidia (see Additional file 3).
Analysis of the top 20 most affected genes indicate that many genes are known mediators of disc degeneration or serve a role in maintaining normal disc function.
More impressively, HuH7 cells showed global overexpression for most AKR genes, indicating that AKR1B10 overexpression is not a unique feature of tumorigenesis.
Figure 4 illustrates the tight correlation between normalization factors generated with the top two (SRP14 and TPT1) and the top five most stable genes, indicating that as few as two genes may be sufficient for reliable normalization within failed and non-failed myocardium.
Function annotation of target genes indicated that most of these differentially expressed miRNAs tend to target genes involved in signal transduction and cell communication, epically the MAPK signaling pathway.
The presence of a few chicken chemokine and chemokine receptor paralogs and orthologs of the mammalian genes indicated that most chicken chemokine and the receptor genes shared common ancestors with the human and mouse genes.
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