Goodfellow and his ICRF colleagues figured that if they could understand what decided whether a person grew male or female sexual organs the most fundamental of developmental decisions they might better understand the erroneous decisions made by cells at the start of cancer.
How complex three dimensional structures such as tissues and organs are formed from precursor cells is one of the most fundamental questions in developmental biology.
Genetic tools, together with advanced microscopy techniques, serve as the most fundamental means for developmental biologists to elucidate the logistics and the molecular control of growth, differentiation and morphogenesis.
LincRNAs with the highest sequence constraint, which might be expected to convey the most fundamental roles, are expressed preferentially during single developmental stages, rather than over multiple stages, and represent the best candidates for further experimental scrutiny into their contributions to developmental processes.
With the recognition of the lack of knowledge in developmental biology and developmental neurotoxicology, we encourage exploration of the most fundamental research issues.
Since these fundamental developmental processes are among the evolutionary most conserved, we hypothesize that the underlying genetic networks and their interaction patterns are also highly conserved.
In addition, this information could be used to construct a genomics/proteomics database for predicting developmental neurotoxic potential across species at the most fundamental level of homology.
Consistent with developmental principles, independence is achieved at lower stages in the most fundamental activities of eating, transfers, and communication.
Indeed, understanding the causal trajectory that leads to autism within the first 3 years of life remains the most fundamental question in autism research, and the most important if we are ever to intervene effectively to alter that developmental trajectory.
The appearance of these three together, they felt, was not fortuitous; all were expressive of a single, fundamental developmental disturbance.
