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The first reason that comes to mind is that p24 is one of the most functionally and structurally constrained proteins of HIV.
A likely contributor is the fact that the p24 capsid protein is one of the most functionally and structurally constrained proteins of HIV-1 [26] [39], [39].
Isoprenoids, also known as terpenoids, represent the most functionally and structurally diverse group of natural products.
Isoprenoids are the most functionally and structurally diverse group of natural products from which numerous medicines and relevant fine chemicals are derived.
B. subtilis PSMR subclass sequences were selected as the comparison set for Syn-SCAN analysis since they represent the most functionally and structurally characterized members of this subclass to date [ 21, 22, 25, 26].
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Proteomic data also added footnotes to this notion, where the most functionally important and representative genes, including LEA3, sHSP, Bowman-Birk trypsin inhibitor, Lipoprotein and lectin, thaumatin-like protein were found as up-regulated DEGs.
We believe this reflects, with each round of filtering, a progression from a terminal bias arising due to genome-wide selective pressures in C-terminal residue composition to the most functionally distinct and biologically relevant C-terminal tripeptides.
We show that there is no one scale of interest in the community structure of the yeast protein interaction network, but we can identify the range of resolution parameters that yield the most functionally coherent communities, and predict which communities are most likely to be functionally homogeneous.
The more detailed methods employed in this study that distinguished between SNs of the suborbital bone and in the eye orbit enabled Yoshizawa et al. [ 2] to highlight the most functionally important SNs, and led to the detection of a strong positive correlation between these traits.
An alignment of 327 amino acids showed that only 52 sites (∼15.9%) were variable and most functionally important residues were highly conserved (Figure S1, Supplementary Material online).
The clade of soluble kinases consisted of 21 distinct published kinase families and most functionally characterized subfamilies form separate clades.
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