Sentence examples for most functional domains from inspiring English sources

However, LT mutants that are defective in p53 binding and truncation mutants (N terminal 1 259 and 1 136 amino acids) that lack most functional domains except the pRb inactivation domain, caused similar levels of antiestrogen resistance as full length SV40 LT or PyLT ([12] and data not shown).

Usually, inactive isoforms are short versions of the fully active protein in which most functional domains are missing [ 36].

Coevolutionary analysis reveals that most functional domains in Hippo genes have coevolved with interacting functional domains in other genes.

Cre-mediated deletion of Apc exon 14 leads to premature termination of Apc peptide, and most functional domains including binding sites for Ctnnb1 and microtubule were truncated [ 7].

Generally, applying evolutionary and coevolutionary analysis to identified functional domains revealed that most functional domains in Hippo genes have not only been under purifying selection but also coevolved with interacting functional domains in other genes.

Finally, combined domain analysis, evolutionary analysis and coevolutionary analysis reveal that most functional domains in Hippo pathway genes have not only been under purifying selection but also coevolved with interacting functional domains in other genes.

The position of the most represented functional domains is reported in figure 5 (see also table 1 for acronyms).

To give an impression about the scope of GBIS, the most important functional domains of Figure 1 are briefly described below.

This hypothesis came from the evaluation of informative families carrying mutations in one of the most relevant functional domains of β myosin heavy chain: the converter region, located between amino acids 709 777 of the protein.

While the classification, based on the most common functional domains from the kinome, is very similar to the classical taxonomy it would also be interesting to try and understand the functional and evolutionary implications of the rare domains appearing only in a certain phyla or fungal species.

A selection of the most relevant markers given in Tables 2 and 3 are further categorised in Table 4 according to the most relevant functional domain (horizontally) while indicating (vertically) whether the markers by themselves are classified into the following groups.