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Most functional data on CXCL12 were obtained from CXCL12α and β, while to date, three isoforms (α, β and γ) and up to six isoforms (α, β, γ, δ, ε and φ) of CXCL12 have been found in rodents [15] and human [16], respectively.
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However, this approach was criticized by Arditi and Akçakaya [ 6] because most functional response data are more consistent with a type II (saturating) model than a type I (linear) model.
As the transcriptome dataset is revised and supplemented with addtional manually curated annotations, the most current functional data will be made available to the community via the public portal and annotation tool.
Most of the functional data available on Bce-like modules so far have suggested that these modules may be involved in antibiotic resistance mechanisms (against bacitracin, vancomycin, LL-37, enduracidin, etc).
Most of the functional data describing QA blockade of potassium channels have been obtained on voltage-gated (Kv-type) channels.
Analysis of the CYH and EFA6 subfamilies, present only in multicellular animals, and that of the large ArfGEFs, found in all eukaryotes, have yielded most of the functional data currently available.
The technologies with the most functional and oncological outcome data are high-intensity focussed ultrasound (HIFU) and cryotherapy.
At first glance, a general evaluation indicates that the Gasch et al. microarray data is the second most reliable source for functional data (Fig. 5a).
The reason lies in that functional data are functions and most algorithms are designed to work with low dimensional vectors.
A state space model was the most common approach for forecasting functional data in these studies (5 papers).
That said, the lack of any structural insight and functional data for most chemosensory genes hinders a direct comparison of ligand sensitivities between orthologous genes.
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