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Arginine is the most frequently substituted residue in both datasets (AASs and harmful AASs) while the substitutions from alanine and glutamate are less frequent among harmful AASs (Additional file 5: Figures S5 and S6).
Five of the seven positions most frequently substituted in the evolved clones are within 15 Å of the phenyl side-chain, but only six of the 48 positions that were mutated once or twice are within that radius.
The arrows in Figure 5 indicate the metagenes that most frequently substituted for the omitted RMG.
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For the thirteen p53 REs aligned to Alu repeats, this ratio varies from 8.7 to 18.1%, in most cases being less than 15%.) Note that the CG dimers have been frequently substituted not only in the CNNG tetramers, as was emphasized by Zemojtel et al. [ 36], but rather in the whole ~20 bp-long Alu regions corresponding to the p53 sites.
At the beginning of the colonial period, stamped metal foundry pieces frequently substituted for scarce currency.
Sanders, who had served as principal deputy press secretary, frequently substituted for Spicer during daily briefings since May. .
In nature, hemicellulose polymers are frequently substituted with acetyl side chains.
In particular, phosphoserines are more frequently substituted to aspartate and glutamate, compared to non-phosphorylated serines.
Antidepressants and PPIs were found to be less often generically substituted and more frequently substituted from generic alternative to branded, compared to ACE inhibitors and statins.
Instead, thermal destruction or desorption (in which the waste does not directly contact the flame) has been frequently substituted.
Cow's milk and cow's milk-based infant formulas are the most frequently used substitutes for infants who are not breastfed.
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