Optimization of medium compositions by the traditional "one-factor-at-a-time" strategy is the most frequently used process in biotechnology (Haaland 1989).
The most frequently occurring processes (urbanization and abandonment in each period; deforestation, intensification of agriculture and afforestation in one period) are described in more details.
Transport through the skin and the small intestine, although not fully representative of the real situation, are by far the most frequently studied processes in this category.
For example, GO terms Inflammatory response (81%), Immune response (80%), Cell-to-cell signalling (77%), Cell-to-cell adhesion (76%), and Cellular homeostasis (67%) were among the most frequently enriched processes, whereas DNA replication (98%), Regulation of cell cycle (98%), were among the most frequently depleted (Additional File 2).
Factors that help implementation were grouped according to 1) technical quality, of which data availability, validation/verification with historic data/expert opinion, and the development of the conceptual model were mentioned most frequently 2) process quality, with client involvement and 3) outcome quality with, presentation of results.
The most frequently enriched biological processes are nuclear division, immune system process, microtubule-based processes, inflammatory response, response to external stimulus, cell cycle and cell adhesion.
Other sources of verb ambiguity also arise in the presence of grammatical metaphor, whereby a verb that most frequently realises one process instead refers to a different process.
Some of the most frequently used preparatory processes are discussed below.
