Sentence examples for most frequently overexpressed from inspiring English sources
Another histone chaperone that is significantly overexpressed - actually the most frequently overexpressed chromatin factor in cancer - is HJURP, a chaperone of the histone H3 variant CENP-A, which facilitates aneuploidy and genome instability, another hallmark of cancer [ 43] (Additional file 2: Figure S1B; Table 1).
The epidermal growth factor receptor (EGFR) belongs to the family of receptor tyrosine kinases and is one of the most frequently overexpressed proteins in malignant tumors (Ciardiello and Tortora 2008).
This study, analysing laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114; 228 specimen) by GeneChip and quantitative real-time RT-PCR, identifies ETS-related gene (ERG), a member of the ETS transcription factor family, as the most frequently overexpressed proto-oncogene in the transcriptome of malignant prostate epithelial cells.
Following ERG, ETV1 is the most frequently overexpressed ETS gene in prostate cancer (∼10% of the tumors) [10].
For instance, EZH2 appears as the most frequently overexpressed protein methyltransferase.
Myc is a global transcriptional regulator and one of the most frequently overexpressed oncoproteins in human tumors.
Of the four known membrane type matrix metalloproteinases, MT1-MMP is most often overexpressed one in cancer and is frequently detected in association with the activated form of MMP2.
It has been found to be frequently overexpressed in most types of cancer, including HCC, whereas it is undetectable in most normal adult tissues.
The eHsp90-LRP1 complex was shown to regulate activation of the receptor tyrosine kinase EphA2, which is frequently overexpressed in most GBMs and stimulates GBM cell motility and invasion following activation by AKT-dependent phosphorylation at S897 p-EphA2S8977) (Fig. 2).
Survivin (16.5 kDa) is the smallest member of the IAP family containing a single baculovirus IAP repeat motif and it is frequently overexpressed and/or deregulated in most neoplastic tissues.
This region of chromosome 11 contains several genes, most notably CyclinD1 and ESM1/Cortactin, which are frequently overexpressed, mainly through amplification, in a variety of human cancers (Schuuring, 1995; Ormandy et al, 2003).
