Consistent with our own data, codon 146 was the most frequently mutated of the mutations described.
Interestingly, TP53 was the second most frequently mutated gene, with seven mutations identified.
Most frequently mutated was PIGA, with seven mutations.
Many alleles of the two most frequently mutated genes, ACE2 and UBR1 were nonsense mutations.
We identified MUC4 as the most frequently mutated gene in all three individuals acquiring >75 mutations.
The most frequently mutated gene in this study was BRCA2, with four protein truncating mutations.
Unsurprisingly, TP53 was the most frequently mutated tumour suppressor gene with >40% of patients harbouring a missense or truncating mutation.
The most frequently mutated gene was PIK3CA (27%) followed by CDH1 (20%).
As expected, TP53 and RB1 are the most frequently mutated genes in this cohort of patients.
The most frequently mutated gene is MYBPC3, encoding cardiac myosin-binding protein-C (cMyBP-C).
The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas.
