Sentence examples for most frequently dysregulated from inspiring English sources
Established roles for the Pim kinases in MM are diverse and include MM proliferation, survival, cell cycle dysregulation, an oncogenic collaboration with the most frequently dysregulated gene in MM (Myc) and mediating bone destruction.
The most frequently dysregulated genes include BCL-6, BCL-2, and cMYC [ 12].
The PI3K/Akt/mTOR pathway is one of the most frequently dysregulated signaling pathways in cancer and an important target for drug development.
(18) Various alterations of the proto-oncogenes and tumor suppressors along this pathway mark this network as one of the most frequently dysregulated signaling cascades in cancers.
c-Myc is one of the most frequently dysregulated oncogenes in various human cancers, including NPC and its expression is induced by EBV-encoded genes, such as LMP1 (ref. 13) and LMP2A.
c-Myc is one of the most frequently dysregulated oncogenes in human malignancies, and it regulates multiple processes including uncontrolled cell proliferation, cell growth, genomic instability and tumor cell metabolism.
Hereby, the male children most frequently utilized dysregulated aggression compared to the female children.
Likewise, our signature did not contain any of the most frequently reported dysregulated genes in microarray studies comparing HN squamous cell carcinoma versus normal mucosa 26 (data not shown).
Although our 15-gene signature did not contain any of the most frequently reported dysregulated genes in microarray studies of NSCLC 25 and HNC 26, we identified a subset of lung and HN gene signatures showing statistically significant gene overlap with our signature, including NSCLC and HNC signatures derived from gene expression profiling of dissected tumors and adjacent normal tissues.
23 ErbB signaling is frequently dysregulated in human cancers, one of the most common mechanisms of which is amplification of the ERBB2 gene, 24 resulting in overexpression of the surface receptor HER2 and constitutive signaling.
P53 was frequently dysregulated in both dysplastic and carcinoma samples (44 out of 76; 57.9%).
