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Among them, the most frequently downregulated genes in tumors were NP_775756 and ZNF537, from the homeobox gene search and the genome-wide search, respectively.
The second one is the group of metallothioneins (MT1L, MT1G, MT1E, MT1X, MT1B, MT2A, MT3) found to be downregulated in 65 to 85% of relapses depending on the MT. MT3, also known as neural growth inhibitory factor, was the most frequently downregulated gene among metallothioneins.
We found that, of those, RASSF2A is the most frequently downregulated in gastric cancer.
Of the 10 genes analyzed, the expression of RASSF2 was the most frequently downregulated in gastric cancer.
Among the eight RASSF family genes and MST1/2, we found that RASSF2A is the most frequently downregulated in gastric cancer cell lines.
We examined the expression profile of eight ras-association domain family (RASSF) genes plus MST1/2 and found that RASSF2A is the most frequently downregulated in gastric cancer.
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