Sentence examples for most frequently deregulated from inspiring English sources

The Wnt/β-catenin pathway is the most frequently deregulated pathway in hepatocellular carcinoma (HCC).

How is Hippo signalling most frequently deregulated?

PI3K-AKT-mTOR cascade is one of the most frequently deregulated pathway in cancers [9], [10], [11].

We focus on the central growth-regulatory pathways that are most frequently deregulated in cancer.

The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human tumors.

The PI3K/PTEN/Akt pathway is one of the most frequently deregulated pathways in human cancer.

The above findings taken together clearly indicate that hnRNP A1 is the most highly and frequently deregulated protein in NSCLC.

The oncogene c-MYC is one of the most crucial and frequently deregulated proteins in human cancers [ 4]. c-MYC is a regulator of S-phase entry, proliferation, and differentiation [ 5], and has the ability to drive both proliferation and apoptosis [ 4, 6- 8].

Most recently miRNAs were found to be frequently deregulated in HCC, and some specific miRNAs were found to be associated with the clinicopathological features of HCC, such as metastasis, recurrence, and prognosis (reviews by Braconi and Patel, 2008; Ladeiro et al, 2008; Mott, 2009).

The extracellular signal regulated kinase (ERK) pathway is the most studied of the mammalian MAPK pathways and is frequently deregulated in many cancers.

This critical cell cycle machinery is frequently deregulated in CRPC, with CCND1 amplification and/or RB1 loss the most recognized genomic contribution, detectable in 5 8 and 30% of CRPC, respectively (Bubendorf et al, 1999; Grasso et al, 2012).