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While RIC8A is located in one of the most frequently deleted regions in breast cancer [ 27], the deletion obviously involves a large number of genes.
Interestingly, Anduril-based analysis of the two most frequently deleted genes at 9p21.3, MTAP and CDKN2A, shows that even though the gene deletion is an explanatory factor for lower expression of these genes in patients with deletion, in total GBM patient material the MTAP expression is not inhibited and CDKN2A is overexpressed compared to normal tissue (Additional file 4).
The most frequently deleted MCR was 3p14.1 <60.43 60.53> that removed the fifth exon of FHIT.
It resides at the most frequently observed fragile site in the human genome, FRA3B (3p14.2); and it is one of the earliest and most frequently deleted regions in multiple cancer types [8], [9].
Some CAN genes were altered at high frequencies in AAs with EXOC4, EPHB6, GNAS, MLL3 and TBX22 as the most frequently deleted genes and HAPLN1, ADAM29, SMAD2 and SMAD4 as the most frequently amplified genes.
The most frequently deleted area was 6q25.
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Last .fm for example, publishes a chart listing the songs that its users most frequently delete from their public listening-stream data.
Most often deleted region on chromosome 11 was 11q22 area.
For example, miR-15a and miR-16-1 are located at a frequently deleted site in most of the B cell chronic lymphocytic leukemia patients [ 11], and induce apoptosis in a leukemia cell line model [ 12].
Several chromosomal regions have been described to be frequently deleted in gastric cancer, but in most of the regions, no tumour suppressor genes have been described yet.
A minimal region of 8p21-22 was found to be frequently deleted in HCC.
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