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Separate analyses were performed on a gene-by-gene basis for all genes within (a) most frequently amplified regions (CN≥3; Freq≥40%) and (b) most highly amplified regions (CN≥5; Freq≥7%).
In addition, we identified one amplified and overexpressed target gene, cyclin E, in the most frequently amplified target segment of chromosome 19.
The 8q24 cytoband, which was consistently detected as an amplified region by WACE, was found to be the most frequently amplified region by genome-wide array CGH[ 9, 12], where the expression of the underlying genes also reflected the change in DNA copy number[ 12].
MYCN and CCND2 were among the most frequently amplified genes in SHH (Supplementary Table 6), but were also altered in non-SHH cases.
The 15 genes that were the most frequently amplified are located in 17q12 and 8q24 (Table 2).
Among the CAN genes from Sjöblom et al. list [23], the following are among the most frequently amplified in AA patients: SMAD2, SMAD4, ADAM29, and HAPLN1.
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Sort functions for each column allows users to visualize that TP53 is most frequently mutated, amplified, or deleted in OV, HNSC, and KICH respectively.
One of the most frequently (80%) amplified gene in our data set was KHDRBS1 (also known as p62), a cell proliferation and cell surface receptor of signal transduction located at 1p35.1.
DDHD2 is located in a region of the genome that is frequently amplified in breast tumors, and most frequently in ER+ breast tumors [ 42].
Most relevant to the current study is the finding that RAD21 is frequently amplified in two of the four tumor types evaluated.
3q26 is frequently amplified in several cancer types with a common amplified region containing 20 genes.
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most frequently underinflated
most instances amplified
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