Sentence examples for most frequently altered from inspiring English sources

The eleven most frequent nonrandom aberrations in the tumor material are summarized in Table 2. RNO20 was the most frequently altered chromosome and was the only chromosome exhibiting both gains (in three regions) and loss (in one region, Table 2).

Apart from defining the most frequently altered genes in metastatic CRC, this study was also aimed at detailed characterization of the most frequent recurrent breakpoint regions associated with such genetic changes.

The AR and PI3K/Akt/mTOR signaling pathways are the two most frequently altered, representing therefore interestingly targets for therapy.

In hereditary neuroendocrine tumors, the most frequently altered gene is the tumor suppressor gene of multiple endocrine neoplasia type 1 (MEN-1), codifying the menin protein, whose function is unknown.

CDKN2A was the next most frequently altered gene with >20% of patients carrying copy number losses.

The wnt signaling pathway was found to be the most frequently altered in HCC.

The phosphoinositide 3-kinase (PI3K) pathway is one of the most frequently altered signaling pathways in human cancers.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (SMARC) genes, also known as BRG1-associated factors, are among the most frequently altered and best characterized chromatin remodelers in cancer.

The JAK/STAT pathway is one of the most frequently altered pathways in HL.

Glycine-177 (G177, see Figure 3A) is the second-most frequently altered UBIAD1 residue in SCD families (Nickerson et al., 2013).

CHMP7 and CCAR2 were the most frequently genomically altered genes in the signature, in 47% and 42% of samples, respectively.