Sentence examples for most frequently activated from inspiring English sources

Akt is perhaps the most frequently activated oncoprotein in human cancers, and its activation contributes to the genesis of cancer through the inhibition of apoptosis and induction of proliferation.

3 4 In a systematic study of molecular signatures in GC, mitogen-activated protein kinase (MAPK) was found as the most frequently activated pathway in this deadly disease.

Analysis of the patterns of Notch activity revealed by this reporter indicates that although Notch is most frequently activated prior to mitosis it can be activated at any time within the cell cycle.

Consistent with these observations, the brain area most frequently activated in chronic pain patients is the prefrontal cortex [109].

RAS mutations are found in at least 20% of all human malignancies with K-RAS being the most frequently activated oncogene of all RAS proteins [1], [2].

The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development.

What self-schema was most frequently activated during the week?

Many targeted therapies in development act on the PI3K/AKT pathway, one of the most frequently aberrantly activated signaling pathways in human cancer cells.

Recently, all four of these leukocyte-associated TF were identified as the most frequently differentially activated TFs in breast cancer based on a large microarray dataset [88].

Telomerase, a RNA-dependent DNA polymerase silent in most normal human somatic cells, is frequently activated during the oncogenic process [18], [19].

Like MAPK signaling pathways, most of the Int pathways - Wnt, Fgf, and Notch - are conserved regulators of development that are frequently activated to promote oncogenesis.