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The most frequent study type was therapeutic; the USA and UK were the largest producers of published work in these journals, with contributions from other countries increasing markedly over the decade.
The most frequent study design underlying the economic analyses was retrospective database analysis (five of eight economic studies).
The most frequent study drug-related adverse events were hypertension and gastrointestinal toxicities such as anorexia and diarrhoea.
The most frequent study type was some form of trial, the sole study type for 46.4% (77/166) of included reviews.
The most frequent study design was pre-post, followed by prospective, population based case series or consecutive case series, and randomized trials.
Hypertension (23%) and diarrhoea (7%) were the most frequent study drug-related adverse events of CTC grade 3. The maximum-tolerated dose was not reached up to a dose of 1500 mg BID continuous dosing.
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Bioassays investigating pro- and anti-angiogenesis modulation by different bioactive plants were the most frequent studies in natural products.
Some of the most frequent studied genes concerning human longevity were summarized in Table 1.
Most of the articles referred to studies conducted in teaching hospitals (52 articles, 50.5%) and the second most frequent studies' setting was the rheumatologic clinics (31 articles, 30.1%).
2007 *P < 0.05 ** p < 0.01 *** p < 0.001 NA: Does not apply ND: No data The most frequent studies about violence in representative community samples address the issue of victimization.
The articles included the behaviors of 30 species and 40 subspecies of felids, with the most frequent single study species being the domestic cat (Felis catus), followed by several "big cats".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com