Bioassays investigating pro- and anti-angiogenesis modulation by different bioactive plants were the most frequent studies in natural products.
The most frequent study type was therapeutic; the USA and UK were the largest producers of published work in these journals, with contributions from other countries increasing markedly over the decade.
The most frequent study design underlying the economic analyses was retrospective database analysis (five of eight economic studies).
The most frequent study type was some form of trial, the sole study type for 46.4% (77/166) of included reviews.
The most frequent study drug-related adverse events were hypertension and gastrointestinal toxicities such as anorexia and diarrhoea.
Most of the articles referred to studies conducted in teaching hospitals (52 articles, 50.5%) and the second most frequent studies' setting was the rheumatologic clinics (31 articles, 30.1%).
The most frequent study design was pre-post, followed by prospective, population based case series or consecutive case series, and randomized trials.
Most adverse events (AEs) were grade 1 or 2. The most frequent study drug-related AE was diarrhoea (76.7%), with gastrointestinal disorders occurring in 79.1% (docetaxel-related) and 83.7% (PX-866-related).
2007 *P < 0.05 ** p < 0.01 *** p < 0.001 NA: Does not apply ND: No data The most frequent studies about violence in representative community samples address the issue of victimization.
Hypertension (23%) and diarrhoea (7%) were the most frequent study drug-related adverse events of CTC grade 3. The maximum-tolerated dose was not reached up to a dose of 1500 mg BID continuous dosing.
