Even though dauers were usually the most frequent stage in our study, a considerable proportion of samples did contain proliferating C. elegans populations (Table 3).
For instance, in International Federation of Obstetricians and Gynecologists (FIGO) stage I disease (that is, intra-ovarian tumor with no extension, the most frequent stage at diagnosis according to FIGO), no association between outcome and the clinical signs or tumor histology (mitotic, nuclear atypia, ploidy, Ki67 expression) has been undisputedly demonstrated [ 10, 11].
However, mild COPD is the most frequent stage of the disease, with a prevalence of 7.4% in Germany in those aged 40 and above, while the prevalence of COPD grades 2 and 3 is estimated to be 5.0% and 0.8% respectively [ 11].
The hypsarrhythmic pattern is most frequent during stages 2/3 of non-rapid eye movement (non-REM) sleep, followed by waking and arousal, and it does not occur or is greatly reduced during REM sleep [ 35, 36].
Locally advanced and advanced clinical stages were the most frequent (64%) stages in comparison with early stages.
The most frequent tumour stage was T3 (34 out of 65).
The most frequent cases of stage 2 to stage 3A do not respond well to their independent application because retinal exudative change and serous retinal detachment are present at advanced stages of the disease, which obstruct laser therapy.
To ensure that the stage 2 validation of our original findings was not influenced by the differences among case populations, we performed a subset analysis to include only the most frequent diagnoses in both stages, HLHS and D-TGA.
Importantly, diabetic nephropathy is the most frequent cause of end-stage renal disease accounting for more than half of new diagnoses [6].
The most frequent abnormality in late stage 13 spindles was the presence of long, narrow poles (Fig. 2H,I).
