Sentence examples for most frequent somatic from inspiring English sources

The Authors observed that headache was the most frequent somatic symptom in children and adolescents referred for anxiety, depression and behavioral disorders, with a prevalence of females.

A study in a psychiatric setting [48] also showed that headache is the most frequent somatic symptom in children and adolescents referred for emotional and behavioural disorders, as well as in patients with depression and/or anxiety.

The most frequent somatic mutations and Ig gene joints were then introduced into an engineered single-chain Fv (scFv) that expressed the germline-encoded VH and VL amino acid sequences.

LOH at 16q is the second most frequent somatic genetic event in breast cancer.

Recent whole genome analysis demonstrated that TP53 gene mutation is one of the most frequent somatic mutations in breast cancer.

To date, the most frequent somatic molecular alterations identified are activating mutations in the guanine nucleotide-binding a-subunit 1 gene (GNAS) [ 4].

Immediate decision-making, which builds on recognition, was most frequent in somatic problems with emphasis given to symptoms and psychosocial problems with emphasis given to person in contrast to problems registered as somatic and psychosocial where emphasis was given both to the symptom and the person, where gradual decision-making was more often used in.

RUNX1 is one of the most frequent targets of somatic mutations in leukemia and is mutated in an autosomal dominant disorder affecting platelets and predisposing to leukemia development.

Mullighan et al. [ 51] showed that the genes regulating B-cell development and differentiation are mutated in 40% of pediatric ALL and that PAX5 was the most frequent target of somatic mutation being altered in 31.7% of cases.

Based on the literature, the single base substitutions are the most frequent type of somatic mutations (∼500 times more frequent than short insertions/deletions) and protein-coding sequences are less mutagenic than sequences in non-coding regions, assuming that the somatic mutation spectrum in malignant cells is the same as in normal cells.

One of the most frequent alterations are TP53 somatic mutations found in more than a half of the cases.