The most frequent significant atherosclerotic abnormalities (>50% stenosis) were found in the lower leg, namely 12 individuals presenting with mild (2, 1.4% of all subjects respectively), moderate (3, 2.2%), or severe stenosis (7, 5.0%).
The most frequent significant adverse event was infection.
10.1186/s12711-015-0170-0 thele: Distribution of the most frequent significant biological pathways.
The three most frequent significant pathways, considering all measured traits, including PC, were phenylalanine, tyrosine and tryptophan biosynthesis, endocytosis and purine metabolism (See Additional file 11: Figure S4).
The most frequent significant pathways, considering all traits except PC, included purine metabolism, glycosaminoglycan biosynthesis heparan sulfate/heparin, the pentose phosphate pathway, and peroxisome and vascular smooth muscle contraction (Fig. 6) and (See Additional file 11: Figure S4).
The most frequent significant biological pathways for PC across all measured wavelengths were: phenylalanine, tyrosine and tryptophan biosynthesis, endocytosis, purine metabolism, glycosphingolipid biosynthesis lacto and neolacto series, ether lipid metabolism, caffeine metabolism, spliceosome, and the p53 signaling pathway (Fig. 5).
The 16p13.11 duplications were the most frequent clinically significant CNV identified in our cohort.
In focused coding, we looked for the most frequent or significant initial codes to "develop the most salient categories" in the data corpus which "requires decision about which initial codes make the most analytic sense" (Charmaz 2006a, p. 46, 57).
Fatigue, nausea, diarrhea, and lymphopenia were the most frequent clinically significant adverse effects.
The most frequent clinically significant sleep complaint (39.3% of the adolescents) at follow-up was non-restorative sleep.
The most frequent and significant triplet consists of severity of airflow limitation (GOLDCD) and the two emphysema measures EMPHETCD and FV950.
