The most frequent side effects were a temporary flushing and warm feeling and gastrointestinal symptoms including nausea, diarrhea, cramping and vomiting.
The most frequent side effects are somnolence, increase in appetite, weight gain, xerosthomia and constipation [166].
The most frequent side effect is ipsilateral hearing loss, which is seen in up to 10% of cases [64].
Most frequent side effects were: nausea (0.9%), pressure (0.9%) or pain (1.8%) at the injection site, tension type headache (4.6%) and retroorbital pain (1.8%).
Sleep disturbances such as drowsiness are among the most frequent side effects of treatment with antiepileptic drugs, since they can deeply modify both sleep architecture and the sleep-wake cycle.
Even though the compound demonstrated good tolerability in a phase I/II safety study, symptoms related to the gastro-intestinal tract and pain at the injection site were reported as the most frequent side effects.
The dermatological side effects include superficial oedema and skin rash (the most frequent side effects), pustular and/or lichenoid eruptions, erythroderma, graft-versus-host-like disease, and small-vessel vasculitis [8 10].
Cranial flush or heat sensation was the most frequent side effects in 5 patients (25%), followed by a transient and mild bleeding after the syringe was pulled out in 2 patients (15%).
According to researchers, the combination therapy involving sofosbuvir and ribavirin was generally well-tolerated, with the most frequent side effects being mild to moderate headache, anemia, fatigue, and nausea.
