Sentence examples for most frequent replacements from inspiring English sources
The most frequent replacements for self-bioisosteres are the following: halogen replacements (nearly 50%% of all substitutions), ring modifications, and substitutions.
The methodology of using substitution matrices, as demonstrated here for 5-HT6R, allows the identification of the most frequent and most efficient replacements in terms of biological activity and provides valuable suggestions for modifications to existing ligands for the rational design of new, potent and selective ligands for serotonin receptors.
Deep infection of prosthesis is one of the most frequent complications after joint replacement.
The knee (41.6 %) and hip (28.2%%) were the most frequent locations for joint replacement.
But their most frequent and rudimentary targets are replacement parts for their aging fleet of F-14 fighter jets because there is virtually nowhere else but the United States to get them.
Knee osteoarthritis is one of the most frequent indications for total knee replacement (TKR).
As shown in Figure 4, the most frequent extra action performed was the replacement of incontinence material with a median of 2.2 replacements per day (range 0 6).
It allowed us to identify most common AE, to overcome the most frequent errors, to check the equipment (replacement of batteries for example), and to implement a reproducible protocol for IHT, with training of junior physicians, but also of nurses [29 31].
The G>T transversion at nucleotide 389 leading to the G130V replacement is the most frequent missense mutation in FRDA, found in more than ten Caucasian patients from five families ([18], [23] [25] and MK unpublished data).
The valvular lesion is usually isolated, aortic regurgitation being the most frequent type, and often requires valve replacement in the months that follow it's discovery.
The valvular lesion is usually unique, aortic regurgitation being the most frequent type, and often requires valve replacement in the months that follow its discovery.
