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Apart from defining the most frequently altered genes in metastatic CRC, this study was also aimed at detailed characterization of the most frequent recurrent breakpoint regions associated with such genetic changes.
Pediatric migraine is the most frequent recurrent headache disorder, occurring in up to 28% of older teenagers.
Our major goal was to define the most frequent recurrent breakpoint regions in metastatic CRC and the commonly gained and/or deleted genes in the altered chromosomes.
It now appears that these are among the most frequent recurrent rearrangements in cancer.
The most frequent recurrent metastatic site was bone (48.4%), followed by liver (11.6%), lung (8.4%), brain (7.4%) and local recurrence (7.4%).
As a result, the most frequent recurrent sites of HER3 overexpression (IHC 1+/2+) cases were extra lymph node metastasis and/or peritoneal dissemination.
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6 Primary tension-type and migraine headaches are by far the most frequent subtypes of recurrent headache in adolescence.
The peritoneum is one of the most frequent sites of recurrent gastric carcinoma after curative treatment, despite the administration of pre- and/or postoperative systemic chemotherapy.
Aneuploidy may also be a contributing factor in other infertile populations; for example, despite other potential causes, an abnormal embryonic karyotype was found to be the most frequent cause of recurrent miscarriage (RM) [ 7].
Another retrospective study investigating the cause of rCAP in 70 Indian children found that the most frequent illness was recurrent aspiration, followed by immunodeficiency [ 7], and a more recent Spanish study found that congenital cardiac defects and aspiration syndrome were the most represented illnesses [ 8].
Common variable immunodeficiency disorder (CVID) is the most frequent symptomatic primary immunodeficiency, characterized by recurrent bacterial infections, hipogamaglobulinemia and impaired antibody responses [1] [4].
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