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In particular, we found that the most frequent protein and RNA transport activities were found between the nucleus and cytoplasm.
By limiting the hemoglobin dataset to only adult alpha and beta chain mammalian hemoglobins and mammalian myoglobins, the most frequent protein types present in the dataset, the ability of the feature vector method to create clear separation between different groups of proteins is readily apparent (fig. 5).
Among several proliferation markers, Ki 67 is evaluated as the most frequent protein in breast cancer.
The most frequent protein alterations identified were related to energy, oligodendrocyte and phospholipid metabolism as well as Ca2+ homeostasis [ 52].
PDZ domains are among the most frequent protein modules involved in protein protein interactions and directly bind to the carboxyl (C -terminal PDZ motifs of their ligands.
Mutant p53 p.rankedranked fourth in this analysis and 6 other p53 hotspot mutants were among the 15 most frequent protein variants found in human cancer.
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The most frequent prohormones were PCSK1N (5 peptides from the prohormone), PENK (4 peptides), and SCG2 (3 peptides); the most frequent proteins were PEBP1 (8 peptides) and COX5A (3 peptides).
The most frequent proteins were those shared by both species (protein type 5 and 7 for PGRP-S2 and 2, 4, 9 and 10 for PGRP-S3) [see Additional file 2: Table S1].
The list of identified PPI pairs are ranked according to the frequency of the PGN mentions across the whole selected document set, and the most frequent proteins are listed in the top ranks.
Hence, we created a set of N binary attributes referring to the N most frequent proteins in the PPIs selected from HPRD, where N is a parameter used in the creation of the dataset.
Until now, the most frequent target proteins for T- and B-cell responses are associated with either the cell wall (i.e. Ag85b, PE/PPE) or MTB pathogenicity [17].
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