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The most frequent losses observed were in chromosome 10 and 13, where minimal recurrent regions in 10q25.3-q26.11, 13q13.3-q14.2 and 13q14.3-q21.1 were lost in 64% of the samples.
The most frequent losses were of CFA 14 (five of 25 cases, 20%), and of CFA 11 (three of 25 cases, 12%).
Losses at 10q and 13q were variably underestimated, while loss at 8p was among the most frequent losses in all studies.
Most frequent gains in BLCA include regions on 1q, 5p, 8q,17, 19 and 21q, while the most frequent losses occur on 2q, 4, 5q, 6q, 8p, 9, and 13q.
Overall, copy number losses were more common in stage II tumors and the most frequent losses were shared by different tumor stages without a significant difference in frequency (see Additional file 3 and 4).
This includes the most frequent gains observed in our study over all different tumour stages such as 20q, 8q, 7p, 13q, and 17q, as well as the most frequent losses on 1p, 18q, 8p and 17p.
Similar(54)
The marker that showed the most frequent loss of heterozygosity is adjacent to HIC, hence, HIC has been proposed to be a candidate tumor suppressor gene.
This MCR, that we found in a single case of t-AML (table 7), is the most frequent loss of the table 8 with 7.1% of in p-AML and 10% of in t-AML.
Chromosome 6q was the most frequent loss region.
Concerning CN loss, 6q was the most frequent loss in PIOLs (7/16; 44%) and was also the most frequent (7/12; 58%) loss in IOCNSLs (Fig. 2a).
The most frequent loss of heterozygosity (LOH) was observed on the long arm of chromosome 10 (14 of 30, 47%), which was commonly detected in grade 1 cancer.
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