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The most frequent loci of manifestation are the lungs.
In the cases, the most frequent loci were 9p, 17p, and 5q.
Moinfar and colleagues [ 60] demonstrated that 77% of columnar cell lesions (either with or without atypia) harbour chromosomal abnormalities at least in one locus and the most frequent loci of LOH were 11q21-23.2, 16q23.1-24.2, and 3p14.2 [ 60].
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The most frequent locus in the control group was 9p.
We have previously reported that recurrent homozygous deletions appear to specifically target MAP2K4 in primary ovarian tumors, and the gene lay in a minimal region of loss of heterozygosity (LOH) in 68% (72/106) of the cases, the second most frequent locus targeted by LOH [ 18].
HLA-B*5801-DRB1*0301 at a high frequency in studied population is also the most frequent two-locus haplotypes in other populations such as the Kinh population in Vietnam (4.10%), Han from Southern China (3.00%), Dai (4.40%) and Maonan (4.20%).
Isolates were selected to represent diverse sources and to include the six most prevalent sequence types (ST) and most frequent alleles for each locus.
The frequency of the most frequent allele for each locus ranged from 0·37 to 0·85 (Table 1).
These differences are illustrated by the number of mutational steps separating the most frequent alleles at each locus.
A total of 43 427 SNPs were retained and any missing genotypes for these SNPs were replaced by the most frequent genotype at that locus.
Sequencing of the most frequent fragments confirmed CAVIII locus specific amplification and allowed the determination of the number of repeated units for each fragment amplified (Table 1).
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