Sentence examples for most frequent isoform from inspiring English sources
The second most frequent isoform was variant 6 which results in the loss of 69 of these same amino acids.
K-Ras protein, which is the most frequent isoform of oncogenic Ras proteins, was reported to get geranylgeranylated and remain fully active when FTase activity is inhibited.
E3/E3 genotype was the most frequent isoform found in all groups compared to the other genotypes which corresponds to previous reports [ 13, 41].
The next most frequent isoforms were TRPC1 and TRPC6 reaching about 10% of the level of TRPC3 in heart and diaphragm (Fig. 3).
The most frequent differences between isoforms resided in mutual exchanges of glutamic (E) and aspartic (D) acid residues (more than 20%% of all substitutions; Fig. 3).
The position with the most frequent differences between isoforms (T46 in spinach PsbO) is located in G1 domain, the position with the second most frequent differences between isoforms (E139 in spinach PsbO) is in G4 domain (see positions 47 and 140 in alignment in Additional file 2).
Through the accidental occurrence and loss of novel poly(A) sites in the 3' UTR, natural selection would thus tend towards a topology involving a minor short isoform and a major long isoform, which is indeed the most frequent topology observed for polyadenylation isoforms [ 2].
The outcome of these approaches have shown SEs as the most frequent AS event in mRNA isoforms in human and other mammalian organ systems and cell types, followed by A3Es and A5Es, in turn followed by RIs [ 10].
This represents the normal and most frequent use of constitutive transcripts or isoforms in different tissues.
A quantitative analysis of the isoforms indicated that most of the spliced genes have one major isoform and tend to simultaneously co-express a low number of isoforms, typically two, with intron retention being the most frequent alternative splicing event.
The most frequent translocation in ESFTs is the EWSR1/FLI-1 translocation t(11 22)(q24 q12) leading to different isoforms, composed of the NTD of EWS (chromosome 22), fused in frame to the CTD of FLI (chromosome 11).
