The most frequent gain in PIOL (13/16; 81%) was located on 1q, which was also the most frequent gain (8/12; 67%) in IOCNSLs (Fig. 2a).
The most frequent gain regions of PIOLs and IOCNSLs were located on 1q.
In contrast, CN gains on 1q, which were the most frequent gains in PIOLs, were found infrequently (<10%) in FL, MALT lymphomas, and MCL.
Chromosome 20 showed a common pattern being one of the most frequent gains both in near-diploid and near-triploid NBTs.
The aCGH data set was studied further by identifying commonly aberrated regions [ 33], which showed most frequent gains in 8q and 1q.
The 10 most frequent gains and losses for each gene class are shown in Additional file 4 (complete list available on request).
Conversely, the three most frequent gains found in DLBCL (>30%; 1q, 12q, and 18q) were detected in >63% of PIOLs (Figs. 1, 2a).
14 Among the nine most frequent gains in PIOLs (≥50%), only CN gains on18q were frequent in FL or MALT lymphomas (>20%), and only two gains, on 3q and on 18q, were frequent in MCL (>30%) (Fig. 2a).
This includes the most frequent gains observed in our study over all different tumour stages such as 20q, 8q, 7p, 13q, and 17q, as well as the most frequent losses on 1p, 18q, 8p and 17p.
Most frequent gains in BLCA include regions on 1q, 5p, 8q,17, 19 and 21q, while the most frequent losses occur on 2q, 4, 5q, 6q, 8p, 9, and 13q.
