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For the neighbor-counting method, the most frequent enzyme class in the neighboring domains is considered as the predicted enzyme class for the central node.
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Despite efforts to increase the sensitivity of the method by increasing the sample volume, we were unable to detect blaTEM, and blaSHV, the most frequent enzymes among Enterobacteriaceae.
Molecular function was classified into 14 reference terms, with the most frequent terms being "other enzyme activity," followed by "transporter," "transferase activity," "other binding," "hydrolase activity," and "kinase activity".
The Department of Health and Human Services (DHHS) [ 4] and British HIV Association (BHIVA) [ 6] recommend the most frequent monitoring of liver enzymes, at least every 3-6 months.
The most frequent treatment-related AE involved hepatic enzyme increases.
The R122H mutation of this enzyme is the most frequent one and it is reasonable to assume that transgenic expression of this protease in animals could serve as an experimental model for pancreatitis.
This result was in accordance with what has been observed in different studies in other countries, in which the transferable aminoglycoside-modifying enzymes were the most frequent mechanisms in aminoglycoside resistance in P. aeruginosa [ 25, 1, 26].
Both enzymes and transporters are the most frequent subjects of HGT (Fig. 5c).
It usually manifested as conjugated hyperbilirubinaemia or deranged liver enzymes and was also the most frequent reason for withdrawal of fluconazole in both neonates and paediatric patients.
Obstructive jaundice and/or abdominal/back pain were the most common pre-operative symptoms and elevated values of pancreatic enzymes and cholestasis parameters were the most frequent laboratory abnormalities.
The most frequent rs1801133 SNP (Ala>Val) in the MTHFR gene renders the MTHFR enzyme thermolabile and is linked to moderate hyperhomocysteinaemia [ 14].
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