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(C) Top 20 most frequent domain function combinations (counting >50).
The commonality between these studies is that family was consistently nominated as the most frequent domain.
Two of the most frequent domain mutations, which show resistance to Imatinib (MutY253F and E255K), responded to treatment with AZD0530.
The second most frequent domain, Fibronectin type III domain (fn3), belongs to the Ig-like fold superfamily.
The most frequent domain tethered to protein kinase domain is the immunoglobulin I-set domain, a member of the immunoglobulin superfamily.
The majority of FH2 proteins analyzed appears to contain a rather limited selection of additional domains outside FH2, with the canonical GBD/FH3-FH1-FH2 setheeing the most frequent domain architecture.
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The first step in this project was to determine the most frequent domain-specific predicates represented in the data.
Protein kinase, cytochrome P450, and the RNA recognition motif were the most frequent domains.
The most frequent domains were PF00527 and PF00098, which were conserved among five species from Papillomaviridae and Retroviridae family, respectively.
Ortho script was also able to compute the most representative Pfam IDs of each species (exclusive domains relative to other species and most frequent domains).
The 215 RGAs contained different types of conserved domains; LRRNT/LRR, NB-ARC and PKc/PKc_like were the three most frequent domains in RGAs (Table 1).
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