Pharyngitis, one of the most frequent diseases caused by GAS, is highly prevalent in school-age children in temperate climates and a major cause of antibiotic use.
The three-base-pair deletion c.1521_1523delCTT (p.Phe508del, F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most frequent disease-causing lesion in cystic fibrosis (CF).
In the present study we have investigated in detail how the most frequent disease-causing mutation in the MTRR gene, the deep intronic mutation c.903+469T>C, leads to pseudoexon inclusion.
The mouse Cln3 Δex7/8 gene mimics the most frequent disease-causing human mutation (Cotman et al., 2002).
This created a 'knock-in' of exon 7/8-deleted Cln3, to mimic the most frequent disease-causing human mutation (Cotman et al., 2002).
Results The two most commonly utilized mouse models of juvenile Batten disease are Cln3-knockout (Cln3−/−) and Cln3 Δex7/8-knock-in mice, the latter mimicking the most frequent disease-causing human mutation.
The weak correlation between the CFTR genotype and liver expression in CF patients emerged from studies on patients bearing F508del (the most frequent disease-causing mutation) and expressing a discordant liver phenotype.
The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3-knockout (Cln3−/−) and Cln3 Δex7/8-knock-in mice, the latter mimicking the most frequent disease-causing human mutation.
Worldwide, coronary heart disease (CHD) represents the most frequent disease and cause of death.
Migraine (M) is one of the most frequent diseases recognized as a cause of disability, with a relevant influence on the quality of life, particularly in women.
Bovine mastitis is one of the most frequent diseases in dairy cattle and causes major economic losses due to reduced milk quantity and increased costs of treatment [ 1].
