Sentence examples for most frequent alterations from inspiring English sources

Nearly half of the patients (48%) had their oral hypoglycaemic regimen altered (table 3); the most frequent alterations were stopping sulfonylurea (46%) followed by initiating meglitinides (23%), stopping metformin (21%) and stopping thiazolidinedoine and dipeptidyl peptidase 4 inhibitors (19%).

Aberrant DNA methylation of the CpG site is among the earliest and most frequent alterations in cancer.

Study of the molecular biology of these tumors has revealed that the most frequent alterations are found in genes related to regulation of gene transcription, those regulating the cell cycle, and genes maintaining genome stability.

Advance in our knowledge of the human genome has provided a comprehensive picture of commonly mutated genes in patients with HCC including mutations in the TERT promoter, CTNNB1, TP53 and ARID1A along with other amplifications (FGF19, VEGFA) or homozygous deletions (p16) as the most frequent alterations.

Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL).

This makes CIP2A overexpression together with MEK1/2-ERK pathway activation as one of the most frequent alterations in human cancers.

Distortion was the most frequent alteration in the three types of AOB, and the most altered phonemes were / d /in 62.9 %, and / t / in 51.5 % (Table  2).> No significant association between different types of dyslalias with mild, moderate and severe AOB (p-value = 0.974) (Table  3) was found.

S-cone deficit (56.2%) was still the most frequent alteration detected in our sample.

The most frequent alteration found on the surface of the stone is the grey-black microbial crust, consisting of three different systematic groups: coccoid and filamentous Cyanobacteria, belonging mainly to the genera Chroococccus, Gloeocapsa and Tolypothrix, and green algae often associated with microscopic fungi or lichenized.

For EGFR, CNGs were the most frequent alteration, although mutations or both changes were present in prominent subpopulations.

The most frequent alteration in tumour tissue was decreased expression of KIP2 identified in 9/24 (37%) specimens.