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Based on the Benchmark Dose Technical Guidance, most fitting methods will provide a global goodness-of-fit measure, usually a p-value.
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One difficulty in dealing with GWAS data is that the SNPs are correlated, while most distribution fitting methods in statistics apply to independent observations.
These advantages could help increase the applicability of the method to large complexes, which most existing fitting methods cannot handle.
For example, most current fitting methods, even if couched in chemical terms, express reaction rates in fluorescence units (e.g. Tian et al., 2007), rather than in molecules or moles.
It is found that a weighted least squares regression is the most effective fitting method for the analysis of small samples of glass strength data.
The parameters obtained from the most successful fitting method, as determined from the AIC scores, were used subsequently to estimate the shifts produced by cocaine in the value of the location parameters, Fhm and Pe.
With clear images and fixed and controlled artifacts most of the alternative fitting methods cited in this paper should find the boundary without problems.
For the most recent, a fitting method of L-moments is described in detail for the estimation of its three parameters, also a fitting by minimizing the quadratic mean error through numerical optimization is proposed.
Many fitting methods have been developed, most of which rely on the cross-correlation function (CCF) between the component structure and the density map as a measure of goodness-of-fit (Fabiola and Chapman, 2005).
The substitute was a most fitting hero.
(Well, O.K., "working" may not be the most fitting term).
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