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The spatial disposition of the heterocyle and para-cyano-substituted ring in 2 b and 18 b resembles that present in the most potent enantiomers of the chromenone-based AI series,[ 49] suggesting that this is the most favourable orientation of these groups for potent aromatase inhibition.
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For each ligand, the energetically most favourable orientations for interaction with the Ubc13 surface were computed and ranked with CDOCK [39] (Tables S1 and S2).
When two proteins bind freely in solution they are largely unhindered in their rotational movement so they can align themselves using the most energetically favourable orientation which gives them the optimal protein-protein binding energy.
Molecular dynamics simulations involving the sub-nanoscale interface reveal a most favourable set of temperature independent orientations of the monolayer graphene sheet with an angle of ∽15° between its armchair direction and [010] axis of the silicon substrate.
The main and interaction effects have been discussed on the basis of adsorption at most favourable surface sites, different modes of orientation of DDA species, competition with kerosene, and probable collecting properties of the frother used.
In the piperazine compounds, the phenyl ring preferentially adopts a perpendicular orientation, whereas an almost planar orientation seems to be the most favourable conformation for the tetrahydropyridine compounds.
The orientation was studied first resulting east/west the most favourable because the total solar radiation intercepted was maximum, increasing 5% with regard to horizontal placement, and the exposure resulted to be the most homogeneous over the year.
State-approved foundations benefit from the most favourable tax regime.
It's the most favourable definition of me.
He was 200-1, and that was one of the most favourable odds offered.
The bank offering the most favourable terms wins.The financial environment has been a challenge for MaxBips.
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