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Similarly, the genetic make-up of Plasmodium falciparum, the parasite that causes most fatal malaria cases, suggests that many different strains of malaria should exist in a host population: in reality, however, only a small number of strains, each with distinctive clinical and epidemiological features, are observed.
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However, metabolic acidosis has been reported in most fatal P. knowlesi malaria cases (7, 10, 11, 18, 25 ), and, as with P. falciparum malaria, is likely a late complication signifying poor outcome.
Plasmodium falciparum causes the most fatal form of malaria and accounts for over 1 million deaths annually, yet currently used drug therapies are compromised by resistance.
Nonetheless, this study demonstrates the ability of P. knowlesi to cause fatal malarial disease in adults, despite optimal therapy, and that P. knowlesi remains the most common cause of fatal malaria in adults in Sabah.
P. falciparum and P. vivax cause the majority of infections, with P. falciparum responsible for most cases of severe and potentially fatal malaria.
Plasmodium falciparum malaria is presently among the most fatal diseases in the East African highlands, where an estimated 34 million people remain at risk [ 1].
Malaria is still one of the most fatal diseases in the world.
Although the mortality of malaria infections is declining, the disease, of which malaria tropica (caused by P. falciparum) is the most fatal form, belongs still to the most important infectious disease to man.
Scientists believe they have finally figured out how the mutation that causes sickle cell anemia also protects against fatal malaria.
Most fatal injuries occurred in the 20 40 year age group.
On 23 December 1972 at 16 30, the company's most fatal accident occurred.
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