The most extensive interaction surface is composed of loop 8/9 and Sec61γ, which together contact the backbone of the 28S rRNA and ribosomal proteins uL23 and eL29.
During the revision process of this manuscript, we also observed that the network is in good agreement with recent and extensive reviews on nuclear receptors (from the special issue of Pharmacological Reviews) and still contains the most extensive interaction dataset [ 34- 41].
This 3.0 Å structure illustrates one of the most extensive interaction surfaces of the published high resolution chromatin factor-NCP structures, including 28 Sir3 BAH domain residues and greater than 30 histone residues (and potentially nucleosomal DNA at the BAH domain N-terminus).
The most extensive studied STAT3/miR interaction is the STAT3/miR-21 pathway [ 25– 28].
The helix-rich region spanning helices A, C, G, H, and I, combined with strands 3C and 4C, form the most extensive surface that is compatible with interaction with the antibody.
The concept of ecosystem services as developed for the Millennium Ecosystem Assessment (MA) is currently the most extensive, international, scientific concept dealing with the interaction between the world's ecosystems and human well-being.
Together, these observations are most easily explained by the hypothesis that the catalytic domains have extensive interactions and regulate each other's activities.
Our study presents the most extensive profiling of erythrocyte RNAs to date, and describes primate-specific interactions between the key modulator miR-4732-3p and TGF-β signaling during human erythropoiesis.
Previously, the most extensive comparison of experimental and theoretical salt dependence for an RNA−protein interaction involved fragments of the phage λ N protein and its cognate RNA.
