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SO4 shows increased RDs for PTB across categories of gestation and with most exposure windows.
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Additionally, it might be necessary to characterize the most adequate exposure windows and assessment setups for bioactivity identification.
Some studies optimized bioassays by identifying the most adequate exposure windows and assessment setups to maximize the specific endpoint response and minimize the interference of acute toxicity [41].
The most critical exposure window for the risk of developing type 2 diabetes is not known.
Accordingly, future studies should force to collect exposure information that in a better way reflect the most relevant exposure window.
The last trimester may be the most important exposure window with regard to many aspects of neurodevelopment (Grandjean et al. 1999a; Kershaw et al. 1980).
Most also examine exposure windows spanning a month or a trimester in length, which may mask temporal variability.
The first and third trimesters of pregnancy corresponded to the exposure windows most clearly associated with effects on birth weight, for both exposure models.
Most studies on IUGR used trimester-specific exposure windows.
Our findings showed that the association between maternal particulate air pollution and newborn mtDNA damage was most significantly associated with first and second trimester exposure windows, pointing to predefined mtDNA oxidative damage in susceptible windows of exposure during pregnancy.
More specific information on exposure windows may improve the risk assessment by identifying the most sensitive windows for evaluation of radon exposure in children (Selevan et al, 2000).
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