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Most exposure doses used in animal studies are several orders of magnitude higher than the levels of PBDEs found in breast milk in our study.
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In studies of most human exposures, dose data are often lacking, beyond a vague "yes-no" or "lots, not much, hardly any".
This raises the critical question of which easily accessible parameter most appropriately describes the exposure dose.
For most subjects with continuous exposure, dose escalation was seen only after the first 2 years of use.
This means a far larger exposure dose may be applied.
The effectiveness of the exposure dose reduction is confirmed.
Does the equipment limit the exposure dose?
Potentially, one could manipulate the degree of exposure (dose) by manipulating the stringency of the intervention.
Note, however, that CEA differs from most LCAs in including environmental fate, exposure-dose, and human health, ecological, and other impacts as equal, integral components of the basic CEA framework (as depicted in Figure 1).
Inhibiting the metabolism of a drug that relies on CYP 3A4 magnifies any associated toxicities inherent to that drug, because most are dose (exposure -dependent (for exposure -dependentcity, QT interval prolongation, and rhabdomyolysis).
For this reason most low exposure studies rely on a dose linear assumption which extrapolates data obtained at high exposures to lower doses assuming that the effect is linearly dose dependent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com