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MYCN is a MYC family member that acts similarly to MYC in most experimental systems [34], [38] and in gene response profiles (Cowling and Cole, manuscript in preparation).
Most experimental systems do not pass this test, as evidenced by the fact that the most popular search interfaces have remained relatively unchanged over time (both for Web search and for bioscience literature search).
Sexually dimorphic behaviors in female rodents have been shown to be masculinized by exogenous estrogens (Ryan and Vandenbergh 2006), and BPA is weakly estrogenic in most experimental systems (Kuiper et al. 1998).
In most experimental systems, the injection of tumor cells into ectopic or orthotopic organs [ 26] is followed by rapid growth of tumors that requires the establishment of new vasculature [ 59].
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First, the most powerful experimental systems for studying development are set up to minimize variation that may be critical to comprehending how evolutionary processes occur in nature.
However, to perform simulations at experimental conditions it is critical to use correct force-field (FF) parameters which are unfortunately not available for most complex experimental systems.
Animal and cell models provide the simplest, most flexible experimental systems, but their relevance to the human disorder is a concern.
In combination with classical techniques such as grafting and lineage tracing, the chicken is now one of the most versatile experimental systems available".
Similarly to most other experimental systems (for recent review see [ 2, 28]) VANGL2 is localized on the opposite site of the cell than DVL, which suggests a high level of conservation of the basic PCP features.
The laboratory mouse offers the most flexible experimental system for development of new psoriasiform phenotypes and previous studies have described transgenic or deletion mutants with skin conditions that resemble human clinical psoriasis [3] [5].
Inbred mice are undoubtedly the most powerful experimental system for identifying modifier genes and an example of their usefulness is the identification of Pla2g2a, encoding a secretory phospholipase, as a major modifier of intestinal neoplasm formation in adenomatous polyposis coli (Apc -deficient mice [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com