Most experimental data support the seeded polymerization.
However, most experimental evidences support the fact that the inhibition of SERCA is primarily involved in the monomeric form of PLN rather than the pentameric form [11], [12], [13].
Perhaps the most direct experimental support comes from work on the so called selective interference effect, which occurs when a person tries simultaneously to do two mental tasks both of which call for manipulation of representations from the same code (i.e., two verbal tasks, or two imagery/visuo-spatial tasks).
However, most experimental evidences supporting anti-cancer mechanisms of green tea polyphenols including the ones mentioned above are mainly obtained from in vitro studies, and whether these mechanisms play significant roles in the cancer prevention/inhibition in vivo are largely unknown.
However, one of the most important experimental supports for this model comes from an unrelated study using Citrobacter rodentium to induce intestinal inflammation in NOD2 −/− mice [ 92].
Although many gene models have been improved by these different approaches, most of them lack experimental support and for species-specific and non-conserved genes the gene model predictions are often incorrect or partially incorrect.
Most experimental in vivo models support the concept of cross-regulation between both cytokines but again some studies yielded opposite results, confirming the fact that the cross-regulation may be context dependent.
Essential revisions: 1) The most important point: much stronger experimental support for the idea that centrosome age contributes to differences in kinetochore microtubule stability must be provided.
To deal with the absence of experimental support for most part of the available proteomes, transfer of functional annotation aiming to provide hints regarding the gene/protein function needs to follow strict requirements to avoid, as much as possible, misclassifications.
The problem besetting those seeking experimental support for atomic theories is most evident in chemistry.
