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Although it can be concluded that most essential tissues involved in gas exchange are affected by hyperoxia shortly after exposure, the precise timing and duration of changes consequential to hyperoxia remain undetermined.
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In addition, our observations again stress the importance of performing pharmacodynamic research in the most essential tissue available, being the tumour.
As cartilage primarily serves a biomechanical function, tissue engineering strategies must ultimately produce constructs able to exhibit the most essential mechanical properties of native cartilage (Diekman and Guilak 2013).
Choosing the right cell-containing "bioink" material is the most essential step for fabricating 3-D constructs with a controlled mechanical and biochemical microenvironment that can lead to successful tissue regeneration and repair.
What's most essential?
Maybe that's their most essential quality.
That is the most essential thing.
It's not the most essential piece.
Which element is the most essential?
The simplest but most essential ones.
The most essential parameter being internal order.
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