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The major positive-charged crevice is located in the interface of N-lobe and C-lobe, in which K160, K171, R174, and K248 contribute the most essential positive charge.
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If clinical outcomes are positive, future investigation should explore which are the most essential elements of the pathway outlined in this study.
Specifically, we observed that among the three model architectures that permit viable oscillations, the basic topology of circadian oscillators in nature coincides with the most robust one formed by an essential negative feedback loop and a non essential positive feedback loop.
The most essential component of tuberculosis control is the early detection and adequate treatment of infectious cases also known as sputum smear positive pulmonary tuberculosis.
Maybe that's their most essential quality.
That is the most essential thing.
It's not the most essential piece.
The simplest but most essential ones.
It is arguably the most essential human perversity.
The third and most essential ingredient was exposure.
"Now it's the most essential thing in life".
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