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According to the gene enrichment analysis for the KEGG pathway, the three most enriched pathways identified are related to brain function, i.e., the pathway groups "Neuroactive ligand-receptor interaction", "Long-term depression", and "Neurodegenerative disorders" (Table 6).
To identify the most enriched pathways, selected genes were also annotated to WikiPathways (http://www.wikipathways.org) using NetAffx database.
The most enriched pathways were ECM-receptor interaction and inorganic ion transport and metabolism pathways (Figure S1B).
As shown in Table 4, pathways in cancer (KEGG: hsa05200) is one of the most enriched pathways among the genes predicted to regulated by AA-derived (P = 3.78e-09) and CA-derived (P = 1.20e-13) mirespectivelytively.
In African Americans, airway inflammation in asthma and role of cytokines in mediating communication between immune cells were the most enriched pathways among the 5 genes (p<1.89*10−2).
The pathway of neuroactive ligand-receptor interactions and the GO term of neurotransmitter binding are one of the most enriched pathways and GO terms of the gregarious 4th instar (G4) up-regulated transcripts, including most neurotransmitter and neuromodulator receptors detected in the locust transcriptome (Figure 5).
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Any pathway that is no longer enriched is consolidated with the most enriched pathway for this iteration.
Both identified the NRF2 pathway as the most enriched pathway, demonstrating consistency between these methods.
The most enriched pathway of the G4 up-regulated transcripts was the neural pathway involving neuroactive ligand-receptor interactions (Figure 5 and Figure S8).
The most enriched pathway is hsa04360: axon guidance ("count" = 8).
The most enriched pathway is neuroactive ligand-receptor interaction (p = 5.36 × 10-5).
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