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The most enriched molecular functions (p≤0.05) included 'catalytic activity' and 'binding'binding
The most enriched molecular function terms were binding (GO: 0005488), catalytic activity (GO: 0003824), structural molecule activity (GO: 0005198).
Table 1(b) and (c) shows the top three most enriched molecular and cellular functions and top three biological functions as revealed by the IPA Tool.
Interestingly, we found that the most enriched molecular function of the DAR-FFC-targeted effecters was 'growth factor activity' (Table 2).
Nucleic acid binding was the most enriched molecular function category up-regulated in Li 2 fiber, whereas sugar binding, transferase activity and galactosidase activity were among down-regulated functional categories (Additional file 6C).
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For each miRNA, the five most relevant networks with their most strongly enriched molecular and cellular functions (P < 0.001) are listed in Table 3. Comparative analysis of enrichment patterns demonstrated that all miRNAs were involved in the regulation of global oncogenic processes like cell proliferation, cell death, and cellular movement.
The most enriched terms of molecular function were binding, such as nucleic acid binding (GO 0003676), iron ion binding (GO 0005506), and zinc ion binding, (GO 0008270).
The most enriched category within Molecular Function was alkaline phosphatases.
The results with the most enriched biological processes and molecular functions are shown as a DAG in Figure 4.
The most enriched GO terms included the molecular function term GO 0015075~ion transmembrane transporter activity (for LOH mutated gene CYP1B1 eQTL), biological process term GO 0050877~neurological system process (for LOH mutated gene ABCA13 eQTL) and cellular component term GO 0005643~nuclear pore (for somatic mutated gene TP53 eQTL) with P-values 6.73 × 10-7, 4.31 × 10-5, and 0.02, respectively.
Across all twenty genes, there is no significant enrichment for gene ontology molecular function, the most enriched category is transcription factor binding (u-shaped, kayak, nejire, and Jra; P=0.090).
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