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During late pregnancy, one of the most enriched categories of genes (functional annotation clustering enrichment score of 4.02) included genes involved in translation, translation elongation and translation initiation (Fig. 5 and Additional file 4: Table S5).
The cluster is enriched (FDR<0.05) for 125 GO categories, representing most enriched categories found in the entire dataset of sensitive strains.
Additionally, the most enriched categories from the down-regulated gene list were response to stress, the cell cycle and regulation of protein kinase activity.
The most enriched categories among the up-regulated genes were amino acid, carboxylic acid and organic acid metabolic processes and among the down-regulated genes were regulation of protein kinase, transferase and kinase activities (Table S5).
Cell adhesion was among the most enriched categories from Gene Ontology analysis of creQTL.
Table 2 lists some most enriched categories ordered in decreasing level of significance.
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Across all twenty genes, there is no significant enrichment for gene ontology molecular function, the most enriched category is transcription factor binding (u-shaped, kayak, nejire, and Jra; P=0.090).
We found that three GO terms are significantly enriched for the decidua with female pregnancy being the most enriched category, consistent with the role of decidua as a principal source of hormones and cytokines pivotal in the maintenance of pregnancy.
The inflammatory response process was the most enriched category over time, including functions predicted to be inhibited as well as activated (Figure 3A).
The most enriched category within Molecular Function was alkaline phosphatases.
Interestingly, the most enriched category was immune response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com