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At steady-state conditions in adult mammals, most endothelial cells are quiescent and are believed to contribute to organ homeostasis and tumor dormancy[54].
Consistently, most endothelial cells were abnormal in human tumor vasculature.
GPR4 is expressed in most endothelial cells and mediates sphingosylphosphorylcholine (SPC -induced angiogenic activitieSPC -induced
It also stains most endothelial cells.
CD105 were observed in most endothelial cells along the cell membrane and/or within the cytoplasm.
Anti-CD105 antibodies stained the complete vessel outlines, most endothelial cells expressing a high level of CD105.
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IL-6 was detected and localized in most vascular endothelial cells, in a few proximal convoluted tubules of the kidney, and in the columnar epithelial cells of the bronchioles of the lung and the vascular endothelial cells of the heart.
Susceptible mice had viral antigen in essentially every hepatocyte (Fig. 2F and table S2), while resistant mice viral antigen was restricted to cells that lack typical hepatocyte morphology, most likely endothelial cells and Kupffer cells (Fig. 2G), consistent with low-pathogenicity Reston virus infection (15).
Susceptible mice had viral antigen in essentially every hepatocyte (Fig. 2F and table S2); whereas in resistant mice, viral antigen was restricted to cells that lack typical hepatocyte morphology, most likely endothelial cells and Kupffer cells (Fig. 2G), consistent with low-pathogenicity Reston virus infection (15).
Herein, we focused on AQP1 which is specifically and strongly expressed in most microvasculature endothelial cells outside the brain [7].
Thus, CD73 on non-hematopoietic cells, most likely endothelial cells, mediated the observed effect on peritumoral edema.
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